 Powder 99% | Anti-Aging Active){kind=small}
Overview. Ergothioneine (EGT, “Hemein”) is a naturally occurring thiol-histidine amino acid found in edible mushrooms, with a chemical structure (C9H15N3O2S) uniquely stabilized by a tautomeric thiol group that resists rapid oxidation. Unlike conventional antioxidants that are consumed instantly, ergothioneine is actively transported into cells — and specifically into mitochondria — via the dedicated OCTN1 transporter. YaoSynBio produces high-purity (≥99%) white crystalline ergothioneine through a proprietary red yeast fermentation platform (Patent CN116926103B), offering a sustainable, scalable, and traceable alternative to mushroom extraction.
Mechanism of Action. Once accumulated within mitochondria, ergothioneine neutralizes reactive oxygen species at their source of generation, demonstrating up to 96.9% ROS scavenging efficiency at 100 µg/mL. Its unusual chemical stability means it persists in tissue far longer than vitamin C or glutathione, providing sustained rather than flash antioxidant defense. Beyond radical neutralization, ergothioneine inhibits tyrosinase activity to reduce melanin synthesis for a brighter, more even complexion, and it protects dermal collagen from oxidative degradation, supporting skin firmness and elasticity. It also helps shield cellular DNA and proteins from UV-induced and environmental oxidative damage.
Applications. Recommended at 0.05%–2%, ergothioneine is water-soluble, heat-stable, and formulation-friendly across a wide pH range, making it ideal for serums, essences, eye creams, anti-aging moisturizers, and brightening ampoules. Its premium positioning and strong scientific narrative make it a signature active for high-end “longevity skincare,” radiance, and urban anti-pollution lines. It pairs synergistically with niacinamide, vitamin C derivatives, peptides, and ectoine. The ingredient is globally compliant: listed in the EU CosIng database under EC 1223/2009 (EINECS 207-841-4), FDA-compliant with self-affirmed GRAS status (2022) in the US.
| INCI Name | Ergothioneine |
|---|---|
| CAS No. | 497-30-3 |
| Molecular Formula | C9H15N3O2S |
| Appearance | White crystalline powder |
| Purity | ≥ 99% |
| Recommended Dosage | 0.05% – 2% |
| Storage | Store in a cool, dry place, sealed, protected from light; 2–8 °C recommended for long-term storage |
| Source | Natural amino acid from edible mushrooms; produced via proprietary red yeast fermentation (Patent CN116926103B) |
| Key Benefits |
